By the nondeterministic spacetime hierarchy, you could show that the problem is $\mathsf {NEXP}$-hard; as $\mathsf {NP} \ne \mathsf {NEXP}$, it is impossible to reduce the problem in polynomial time to any problem in $\mathsf {NP}$, so the problem will not be in $\mathsf {NP}$.
However, if your problem is not nearly that difficult, you may be hard-pressed to prove that it is not in $\mathsf {NP}$; and if it is in $\mathsf {NP}$, you'll be hard-pressed to show that $\mathsf {NP}$ is not Karp-reducible to your problem without assuming that $\mathsf P \ne \mathsf {NP}$.