Summary
As zkutch points out, $\sqrt n!$ is not a well-defined notation since $\sqrt n$ is not an integer when $n$ is not a square.
Here are four approaches to interpret the question. We will not only confirm "it" is indeed $\omega(2^\sqrt n)$, but also give tighter or even optimal estimate as well.
Use $\lfloor x\rfloor!$ instead of x!
The question is about $\displaystyle\frac{\lfloor\sqrt{n}+n-1\rfloor!}{\lfloor\sqrt{n}\rfloor!(n-1)!}$.
Let $k=\lfloor\sqrt n\rfloor$. We have,
$$\frac{\lfloor\sqrt{n}+n-1\rfloor!}{\lfloor\sqrt{n}\rfloor!(n-1)!}
=\frac{\prod_{i=1}^{k}(i+n-1)}{\prod_{i=1}^{k}i}
\ge \frac n1\prod_{i=2}^{k}\frac{n}{i}
\ge(\sqrt n)^2\prod_{i=2}^{k}\sqrt n
\ge\sqrt n^{\sqrt n}$$
Use $\lceil x\rceil!$ instead of x!
As an easy exercise for readers, show that
$$\frac{\lceil\sqrt{n}+n-1\rceil!}{\lceil\sqrt{n}\rceil!(n-1)!}
\ge\sqrt n^{\sqrt n}$$
Let $n$ be a square
This is Steven's approach. Let $n = k^2$ for some integer $k$. So, $k = \sqrt n = \lfloor \sqrt n\rfloor$. In the same way as the first approach above, we have,
$$\frac{(\sqrt{n}+n-1)!}{(\sqrt{n})!(n-1)!}=\frac{\lfloor\sqrt{n}+n-1\rfloor!}{\lfloor\sqrt{n}\rfloor!(n-1)!}\ge\sqrt n^{\sqrt n}.$$
Let us compute a tighter estimate, applying Stirling's formula,
$$m!\sim \sqrt{2\pi m}\left(\frac{m}{e}\right)^m,$$
where $\sim$ means the ratio of the two sides converges to 1 when $m$ goes to $+\infty$.
$$\begin{aligned}
\frac{(\sqrt{n}+n-1)!}{(\sqrt{n})!(n-1)!}&= \frac{(k+k^2-1)!}{k! \cdot (k^2-1)!}\sim \frac{(k+k^2)!}{k! \cdot (k^2)!} \\
&\sim \frac{\sqrt{2\pi (k+k^2)}\left(\frac{k+k^2}{e}\right)^{k+k^2}}{ \sqrt{2\pi k}\left(\frac ke\right)^k \sqrt{2\pi k^2} \left(\frac{k^2}e\right)^{k^2}} \\
&\sim\frac1{ \sqrt{2\pi k} } \left(\frac{k+k^2}k\right)^{k}\left(\frac{k+k^2}{k^2}\right)^{k^2} \\
&= \frac1{ \sqrt{2\pi}}\left(\frac{1+k}{k}\right)^{k^2+k} k^{k-\frac12}
\end{aligned}$$
The inequality $\left(\frac{1+k}k\right)^{k+1}\gt e$ tells us that
$\left(\frac{1+k}{k}\right)^{k^2+k} \gt e^k.$
So we have $$\frac{(\sqrt{n}+n-1)!}{(\sqrt{n})!(n-1)!}=\Omega(e^\sqrt n\sqrt n^{\sqrt n-\frac12}).$$
If instead we use the following stronger fact, which can be proved by either l'hospital's rule or Taylor's series for $\ln(1+t)$, $$\left(\frac{1+k}{k}\right)^{k^2+k}\sim e^{k+\frac12},$$ we obtain,
$$\frac{(\sqrt{n}+n-1)!}{(\sqrt{n})!(n-1)!}\sim\frac1{\sqrt{2\pi}} e^{\sqrt n+\frac12}{\sqrt n}^{\sqrt n-\frac12}.$$
Use $\Gamma(x+1)$ instead of $x!$
The natural extension of factorial to non-integers is $\Gamma$ function. The question is about
$$\frac{\Gamma(\sqrt{n}+n)}{\Gamma(\sqrt{n}+1)\Gamma(n)}.$$
Since $\ln(\Gamma(x))$ is convex and increasing for $x\ge2$, we have
$$\frac{\Gamma(\sqrt{n}+n)}{\Gamma(\sqrt{n}+1)}\ge \frac{\Gamma(\lfloor\sqrt{n}+n\rfloor)}{\Gamma(\lfloor\sqrt{n}+1\rfloor)}$$
So,
$$
\frac{\Gamma(\sqrt{n}+n)}{\Gamma(\sqrt{n}+1)\Gamma(n)}
\ge\frac{\Gamma(\lfloor\sqrt{n}+n\rfloor)}{\Gamma(\lfloor\sqrt{n}+1\rfloor)\Gamma(n)}
=\displaystyle\frac{\lfloor\sqrt{n}+n-1\rfloor!}{\lfloor\sqrt{n}\rfloor!(n-1)!}\ge \sqrt n^\sqrt n.$$
Since we also have Stirling's formula for $\Gamma$ function,
$$\Gamma(x+1)\sim \sqrt{2\pi x}\left(\frac{x}{e}\right)^x,$$
we can proceed in the same way as in the approach above but without requiring $k=\sqrt n$ be an integer. In particular, we can obtain
$$\frac{\Gamma(\sqrt{n}+n)}{\Gamma(\sqrt{n}+1)\Gamma(n)}\sim
\frac1{\sqrt{2\pi}} e^{\sqrt n + \frac12}{\sqrt n}^{\sqrt n -\frac12}.$$