Copying my approach for a similar language, only the numbers are (fortunately!) smaller. Here, the number of 0's is divisible by 2 and the number of 1's is divisible by 3. Maybe it scales for your case. The hard part is the first step, where you need to figure out all combinations of 11-sized strings with six 0's and five 1's, but you can track all possibilities with the help of a tree!
So, here it is:
Step 1: Words accepted by this language should be built up from combinations of the basic strings 00, 111, 10101, 01101, 01011, 10110 and 11010.
The first two regard words where 0's and 1's are grouped together, while the rest regard words such that 0's and 1's are intertwined.
However, the regular expression $$(00\mid 111\mid 10101\mid 01101\mid 01011\mid 10110 \mid 11010)^*$$ produces only part of the language.
For example, it does not produce 01110.
Step 2: To produce such words, in the first basic string, we should allow groups of 1's to appear between the two 0's,
and in the second we should allow groups of 0's between the 1's. Now we have
$$(0(111)^*0\mid 1 (00)^* 1 (00)^* 1\mid 10101\mid 01101\mid 01011\mid 10110 \mid 11010)^*$$
This regular expression still does not completely determine the language. For example, it does not allow the word $10\color{teal}{00}101$.
Step 3: To overcome this, in the last five choices of the regular expression, for every sequence of 1's that does not start at the beginning of the string,
if the sequence is followed by a 0, then we add $(111)^*$ in between.
Similarly, for every sequence of 0's that does not start at the beginning of the string, if the sequence is followed by a 1, then we add $(00)^*$ in between.
The reason why sequences that start at the beginning of the string are not considered is because of the outer kleene star and the first two choices.
The final regular expression is:
$$\left(\!\begin{aligned}
& 0(111)^*0
\mid 1 (00)^* 1 (00)^* 1\mid \\
& 10 (00)^* 1(111)^*0 (00)^* 1
\mid 011(111)^*0(00)^*1\mid \\
& 01(111)^*0(00)^*11
\mid 10(00)^*11(111)^*0
\mid 110(00)^*1(111)^*0
\end{aligned}\right)^*$$
This is already a great mess for multiples of only 2 and 3, the first two primes.
time consuming
for you trying to do it "by hand" (so as to avoid pen&paper) or for a machine following an algorithm of yours? $\endgroup$