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Have the bioinformatic methods like sequence analysis, genome annotation, comparative genomics (and many others), been applied to solve problems outside the field of bioinformatics?

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Of course! The perfect example is Gusfield book. Many of string algorithms came from bioinformatics. For example, sequence analysis algorithms are used in text editors.

PS: Algorithms on Strings, Trees and Sequences: Computer Science and Computational Biology, Dan Gusfield

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