The Art of Computer Programming by Donald Knuth is kind of styled like a collegiate text with exercises at the end of each chapter. However, the material is not in any recognizable form for a standard curriculum, so it is hard to imagine the text actually being used for a particular course. Also, the problems are quite hard, not the usual test-your-understanding exercises normally found in textbooks.
Has the ACP ever been used as a primary text in an actual computer science course? If so, which one?