Following the success of the undirected version:
Karp hardness of an equidistant vertex set
Inspired by the success of this long ago question:
NP-hardness of problem with indices and subsets
We move on asking for the hardness of the directed version of an equidistant set.
Input: A directed graph $G(V, A)$ and a natural number $k$
Output: YES if $G$ has an equidistant vertex set of size $k$, otherwise NO
In this problem, we disallow opposite arcs like $(u,v)$ and $(v,u)$ to be both present in the arc set, i.e. either one of them or none.
$\DeclareMathOperator{\dist}{dist}$An equidistant vertex set is a set of vertices $V'\subseteq V$ such that for every two ordered pairs of vertices $u, v\in V'$ and $w, s\in V'$, we have $\dist(u, v) = \dist(w, s)$, where $\dist(u, v)$ is the length of a shortest path between $u$, $v$. Note that in digraph, it is possible that $dist(u,v)\neq dist(v,u)$.